Alan F. Horwitz

Education

  • PhD, Stanford University, Stanford, CA
  • BA, University of Wisconsin, Madison
  • Postdoc, University of California, Berkeley, CA

Primary Appointment

  • Professor, Cell Biology

Contact

Research Interest(s)

Synapse Formation and Cell Migration in Normal and Pathobiology-Adhesion, Signaling, Imaging and Proteomics

Research Description

Selected Publications

  • Chen L, Vicente-Manzanares M, Potvin-Trottier L, Wiseman P, Horwitz A. The integrin-ligand interaction regulates adhesion and migration through a molecular clutch. PloS one. 2012;7(7): e40202. PMID: 22792239 | PMCID: PMC3391238
  • Choi C, Zareno J, Digman M, Gratton E, Horwitz A. Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophysical journal. 2011;100(3): 583-92. PMID: 21281572 | PMCID: PMC3030238
  • Hodges J, Newell-Litwa K, Asmussen H, Vicente-Manzanares M, Horwitz A. Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology. PloS one. 2011;6(8): e24149. PMID: 21887379 | PMCID: PMC3162601
  • Newell-Litwa K, Horwitz A. Cell migration: PKA and RhoA set the pace. Current biology : CB. 2011;21(15): R596-8. PMID: 21820627
  • Vicente-Manzanares M, Newell-Litwa K, Bachir A, Whitmore L, Horwitz A. Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. The Journal of cell biology. 2011;193(2): 381-96. PMID: 21482721 | PMCID: PMC3080254
  • Parsons J, Horwitz A, Schwartz M. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nature reviews. Molecular cell biology. 2010;11(9): 633-43. PMID: 20729930 | PMCID: PMC2992881
  • Vicente-Manzanares M, Horwitz A. Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells. Biochemical and biophysical research communications. 2010;402(3): 537-42. PMID: 20971064 | PMCID: PMC2991406
  • The matrix revolutions. Nature reviews. Molecular cell biology. 2009;10(10): 653. PMID: 19780224
  • Choi C, Vicente-Manzanares M, Zareno J, Whitmore L, Mogilner A, Horwitz A. Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nature cell biology. 2009;10(9): 1039-50. PMID: 19160484 | PMCID: PMC2827253
  • Vicente-Manzanares M, Choi C, Horwitz A. Integrins in cell migration--the actin connection. Journal of cell science. 2009;122 199-206. PMID: 19118212 | PMCID: PMC2714416
  • Vicente-Manzanares M, Ma X, Adelstein R, Horwitz A. Non-muscle myosin II takes centre stage in cell adhesion and migration. Nature reviews. Molecular cell biology. 2009;10(11): 778-90. PMID: 19851336 | PMCID: PMC2834236
  • Brown C, Dalal R, Hebert B, Digman M, Horwitz A, Gratton E. Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope. Journal of microscopy. 2008;229 78-91. PMID: 18173647
  • Digman M, Brown C, Horwitz A, Mantulin W, Gratton E. Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophysical journal. 2007;94(7): 2819-31. PMID: 17993500 | PMCID: PMC2267137
  • Huttenlocher A, Horwitz A. Wound healing with electric potential. The New England journal of medicine. 2007;356(3): 303-4. PMID: 17229960
  • Brown C, Hebert B, Kolin D, Zareno J, Whitmore L, Horwitz A, Wiseman P. Probing the integrin-actin linkage using high-resolution protein velocity mapping. Journal of cell science. 2006;119 5204-14. PMID: 17158922
  • Nayal A, Webb D, Brown C, Schaefer E, Vicente-Manzanares M, Horwitz A. Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. The Journal of cell biology. 2006;173(4): 587-9. PMID: 16717130 | PMCID: PMC2063867