Adam N. Goldfarb

Education

  • BA, Brown University, Providence, RI
  • MD, Tufts University, Boston, MA

Primary Appointment

  • Professor, Pathology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Elagib K, Goldfarb A. Megakaryocytic irreversible P-TEFb activation. Cell cycle (Georgetown, Tex.). 2014;13(12): 1827-8. PMID: 24866976 | PMCID: PMC4111741
  • Elagib K, Rubinstein J, Delehanty L, Ngoh V, Greer P, Li S, Lee J, Li Z, Orkin S, Mihaylov I, Goldfarb A. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Developmental cell. 2013;27(6): 607-20. PMID: 24369834 | PMCID: PMC3892434
  • Richardson C, Delehanty L, Bullock G, Rival C, Tung K, Kimpel D, Gardenghi S, Rivella S, Goldfarb A. Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response. The Journal of clinical investigation. 2013;123(8): 3614-23. PMID: 23863711 | PMCID: PMC3726169
  • Rubinstein J, Elagib K, Goldfarb A. Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis. The Journal of biological chemistry. 2012;287(23): 19207-15. PMID: 22514271 | PMCID: PMC3365953
  • Talbot A, Bullock G, Delehanty L, Sattler M, Zhao Z, Goldfarb A. Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling. PloS one. 2011;6(8): e23850. PMID: 21887333 | PMCID: PMC3161794
  • Coordinating red cell differentiation with cell cycle arrest: GATA-1 activation of p21. Cell cycle (Georgetown, Tex.). 2010;9(11): 2061. PMID: 20559028
  • Bullock G, Delehanty L, Talbot A, Gonias S, Tong W, Rouault T, Dewar B, Macdonald J, Chruma J, Goldfarb A. Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood. 2010;116(1): 97-108. PMID: 20407036 | PMCID: PMC2904585
  • Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb. Journal of cellular biochemistry. 2009;107(3): 377-82. PMID: 19350569 | PMCID: PMC2775554
  • Yeh J, Munson K, Elagib K, Goldfarb A, Sweetser D, Peterson R. Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nature chemical biology. 2009;5(4): 236-43. PMID: 19172146 | PMCID: PMC2658727
  • Elagib K, Mihaylov I, Delehanty L, Bullock G, Ouma K, Caronia J, Gonias S, Goldfarb A. Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation. Blood. 2008;112(13): 4884-94. PMID: 18780834 | PMCID: PMC2597596
  • Elagib K, Goldfarb A. Regulation of RUNX1 transcriptional function by GATA-1. Critical reviews in eukaryotic gene expression. 2007;17(4): 271-80. PMID: 17725493
  • Choi Y, Elagib K, Delehanty L, Goldfarb A. Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1. Cancer research. 2006;66(6): 2990-6. PMID: 16540647