- Biomedical Sciences Graduate Program | Calendar
  • 30Mar

    Mar 30 "Molecular mechanisms of gating in cyclic nucleotide-regulated ion channels" Pharmacology Seminar by William Zagotta, PhD

    [Pinn Hall 1-17] Student Hosted Seminar Speaker; Contact Adi Narahari (akn4uq) for more details. Molecular Mechanisms of Ion Channel Function: Ion channel proteins are the fundamental molecular elements for the control of membrane excitability and signaling in the nervous system. In response to one or more of a variety of stimuli, including neurotransmitters, voltage, and internal second messengers, ion channels open and allow the passage of certain selected ions across the cell membrane. In this way, channels can transduce these stimuli into changes in membrane potential and/or intracellular levels of calcium, the signals most used by the nervous system. The properties of each ion channel are highly specialized for its particular function. To this end, our long term goal is to determine the molecular mechanisms of the opening and closing conformational changes in ion channels. We have focused on a family of channels that is regulated by the direct binding of cyclic nucleotides, cAMP and cGMP. These channels play a fundamental role in the initial generation of an electrical signal in sensory receptors such as photoreceptors and olfactory receptors, and in the control of the pacemaker activity in cardiac and neuronal cells. To study the mechanism of gating by cyclic nucleotides, we employ a variety of approaches including electrophysiology, site-directed mutagenesis, protein chemistry, site-specific fluorescent labeling, and X-ray crystallography. By the combination of these approaches we believe we will be able to gain new insights into the molecular mechanisms for channel function. http://depts.washington.edu/pbiopage/directories/faculty/entry/wzagotta/

  • 31Mar

    Mar 31 Public Health Grand Rounds: "Living in poverty: Understanding how timing matters for health"

    [UHW/MSB Room 3182] "Living in poverty: Understanding how timing matters for health"

  • 31Mar

    Mar 31 Cancer Center Seminar

    [Pinn Hall 1-14] Presented by UVA Cancer Center, this interdisciplinary seminar series provides a venue for basic-science and clinical faculty to hear about cutting-edge work in all areas of cancer. The series features invited speakers on various relevant subjects, and UVA faculty with expertise in selected topics related to cancer. Speakers in our series represent the major research programs in the UVA Cancer Center: Cancer Cell Signaling, Chemical and Structural Biology, Immunology and Immunotherapy, Molecular Genetics and Epigenetics, Women's Oncology, and Cancer Control and Population Health. Additionally, UVA Oncology Fellows and PhD trainees supported by UVA's Cancer Training Grant have an opportunity to host speakers.

  • 03Apr

    Apr 03 PR Journal Club

    [MR5, Room #3005]

  • 03Apr

    Apr 03 PR Journal Club

    [HEP, 3rd floor, Room #3025]

  • 03Apr
  • 05Apr
  • 05Apr

    Apr 05 Functional genomics studies with human pluripotent stem cells

    [Pinn 1-17 (formerly Jordan)] The Center for Public Health Genomics presents the Genome Sciences Seminar Series (GS3) in both Fall and Spring semesters each Wednesday from 1-2 pm in Pinn 1-17. An outstanding slate of speakers will discuss their cutting-edge research in areas such as systems biology, epigenetics and the genetic analysis of complex disease.

  • 05Apr
  • 06Apr

    Apr 06 "Internal and External Sensory Systems" Pharmacology Seminar by Stephen Liberles, PhD

    [Pinn Hall 1-17] Hosted by Bimal Desai. Neural circuits that generate perception and control behavior are poorly understood at a molecular level. We are interested in understanding how the brain processes external sensory and internal homeostatic signals to initiate behavioral and physiological responses. We study how our senses of smell and taste process different environmental cues (like pheromones, food cues, predator odors) to elicit innate mating, foraging, and avoidance responses. In recent efforts, we are also investigating internal sensory modalities of the vagus nerve. https://liberles.med.harvard.edu/

  • 06Apr
  • 07Apr

    Apr 07 Cancer Center Seminar

    [Pinn Hall 1-14] Presented by UVA Cancer Center, this interdisciplinary seminar series provides a venue for basic-science and clinical faculty to hear about cutting-edge work in all areas of cancer. The series features invited speakers on various relevant subjects, and UVA faculty with expertise in selected topics related to cancer. Speakers in our series represent the major research programs in the UVA Cancer Center: Cancer Cell Signaling, Chemical and Structural Biology, Immunology and Immunotherapy, Molecular Genetics and Epigenetics, Women's Oncology, and Cancer Control and Population Health. Additionally, UVA Oncology Fellows and PhD trainees supported by UVA's Cancer Training Grant have an opportunity to host speakers.

  • 10Apr

    Apr 10 PRPR

    [MR5, Room #3005]

  • 10Apr

    Apr 10 PRPR

    [MR5, Room #3005]

  • 10Apr

    Apr 10 Carter Immunology Center: 2017 Anderson Symposium

    [Pinn Hall Conference Center] The Carter Immunology Center will host the 2017 Anderson Symposium. Four speakers TBD. The John F. Anderson Memorial Lectureship was established in 1955 by Dr. John F. Anderson, a graduate in 1895 of the University of Virginia School of Medicine. Through his most generous gift to the University, it has been possible to establish a lectureship in medical science and public health, which will bring to this medical community, the latest developments in these fields.

  • 11Apr

    Apr 11 Pathology Faculty Meeting

    [HEP, 3rd floor, Room #3025]

  • 12Apr

    Apr 12 Pharmacological Reactivation of Inactive X-Linked MECP2 for Rett Syndrome Therapeutics

    [Pinn 1-17 (formerly Jordan)] The Center for Public Health Genomics presents the Genome Sciences Seminar Series (GS3) in both Fall and Spring semesters each Wednesday from 1-2 pm in Pinn 1-17. An outstanding slate of speakers will discuss their cutting-edge research in areas such as systems biology, epigenetics and the genetic analysis of complex disease.

  • 12Apr
  • 13Apr

    Apr 13 "Circuit-based Mechanisms, Biomarkers, and Treatments for Epilepsy" Pharmacology Seminar by Kevin Staley, MD

    [Pinn Hall 1-17] Hosted by Jaideep Kapur and Mark Beenhakker. Dr. Staley is presenting the Neurology Grand Rounds on Friday 11/14 as the Eric Lothman Lecturer. Our long-term research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation. The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition. Our work on the spread of excitation in neural networks combines fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks. We have found evidence for reentrant or circular patterns of neural activity that resemble cardiac fibrillation and precede seizures. We are currently testing whether this reentrant activation of neural circuits is the earliest stage of a seizure, and the stage at which intervention is most effective. We are also testing whether long-term reductions in the strength of synaptic connections between neurons in epileptic networks can reduce the probability of seizures. http://www.massgeneral.org/children/doctors/doctor.aspx?id=17652#

  • 13Apr
  • 14Apr

    Apr 14 Cancer Center Seminar

    [Pinn Hall 1-14] Presented by UVA Cancer Center, this interdisciplinary seminar series provides a venue for basic-science and clinical faculty to hear about cutting-edge work in all areas of cancer. The series features invited speakers on various relevant subjects, and UVA faculty with expertise in selected topics related to cancer. Speakers in our series represent the major research programs in the UVA Cancer Center: Cancer Cell Signaling, Chemical and Structural Biology, Immunology and Immunotherapy, Molecular Genetics and Epigenetics, Women's Oncology, and Cancer Control and Population Health. Additionally, UVA Oncology Fellows and PhD trainees supported by UVA's Cancer Training Grant have an opportunity to host speakers.

  • 17Apr

    Apr 17 PR Journal Club

    [MR5, Room #3005]

  • 17Apr

    Apr 17 PR Journal Club

    [MR5, Room #3005]

  • 17Apr

    Apr 17 CIC Seminar Series: Nicholas Crispe, MBBS, PhD

    [Pinn Hall 1-17] CIC Seminar Series: Nicholas Crispe, MBBS, PhD

  • 18Apr

    Apr 18 Pathology Seminar Series

    [HEP, 3rd floor, #3025]